Botox™ (Botulinum Toxin)

Botox™, the trade name of botulinum toxin, is a drug produced by the same bacterial organism (Clostridium botulinum) that causes the disease process called botulism.

Tiny, entirely safe quantities of this medication have been used for decades to treat strabismus, facial spasms, spasmodic dysphonia, cervical dystonia, and other neurological disorders characterized by abnormal muscle contractions. Botox is also used by cosmetic surgeons to smooth wrinkles temporarily.

Uses for Botox in the Head and Neck

Botox has many uses in the head and neck. In order of commonness in a laryngology practice:

1. The larynx, for laryngeal dystonia (causing spasmodic dysphonia)
   

   That condition causes a strained/strangled, or whispery quality, “catches,” or “dropouts” of syllables or words. All of these vocal phenomena result from involuntary spasms in the tiny muscles of the larynx. Relaxation of the spasming muscles smooths out otherwise-unpredictable voice quality and reduces vocal effort.

2. The upper esophageal sphincter (cricopharyngeus muscle), for retrograde cricopharyngeus dysfunction (R-CPD), aka the no-burp syndrome
   

   In the untreated condition, this muscle refuses to relax to allow burping. The result is gurgling, bloating, and flatulence. Patients often suffer additional symptoms like painful hiccups, a feeling of mechanical shortness of breath, nausea after eating, and hypersalivation.
   
   In this condition, Botox serves relaxes the cricopharyngeus muscle, allowing burping to commence, and serving as “training wheels” for burping, and in turn resolving the condition permanently in about 80% of patients after a single injection.

3. Eye closure, neck, and jaw muscles for dystonia involving them
   

   Ocular, cervical, oromandibular dystonias (blepharospasm, torticollis, jaw dystonia, respectively). In most medical systems, these are more often treated by neurologists than laryngologists.

4. Muscles inserting on the skull, for migraine headaches

   Tension in these muscles can be the source of migraine pain. Relaxing them with Botox can help.

5. The upper esophageal sphincter for cricopharyngeal spasm (CPS)
   

   This is an uncommon use, for a small subset of persons whose CPS is unusually severe, and non-responsive to lesser treatments. The idea is to “reset” the hypertonicity of the muscle causing the distressing choking sensation.

6. Salivary glands
   

   In certain swallowing disorders where patients are having trouble swallowing their saliva, botox injected into salivary glands can reduce salivary flow.

7. The skin in front of the ear for Frey’s Syndrome

   After parotidectomy (removal of the “spit gland” in front of the ear), tiny secretomotor nerve fibers that supplied the gland can reconnect to sweat glands in the skin. When the patient eats, saliva is no longer produced from the removed gland, and sweat can instead drip from the cheek. Botox can reduce this problem.

8. Facial muscles (cosmetic use)
   

   By relaxing muscles of expression, creases, wrinkles and “action lines” in the skin overlying those muscles are smoothed.

TA-only Paresis after Botox Injection for Spasmodic Dysphonia

This man with adductory spasmodic dysphonia (AD-SD), has had consistent results during 15 years of botulinum toxin injections, administered several times per year. After his most recent (routine, and unremarkable) injection with his longstanding dose, his initial weakness was exaggerated and is only beginning to subside after six weeks. This dramatic “outlier” result that cannot be attributed to botox targeting.  As seen in the photos below, the explanation is instead a right TA-only paresis.

The only reasonable interpretation is that the needle tip has “sheared” the branch of the recurrent laryngeal nerve supplying the thyroarytenoid muscle (leaving branches to the posterior cricoarytenoid and lateral cricoarytenoid muscles (PCA + LCA) undisturbed.

In a practice that supplies treatment to approximately 100 patients per month and ~1200 injections per year, this phenomenon occurs perhaps twice per year.  The voice “always” recovers back to baseline SD symptomatology, but excessive breathiness starts to resolve only 6 weeks after the injection.

Lifting the CPM for a R-CPD Injection

These are intra-operative photos of one of nearly 1500 persons treated for R-CPD as of September 2023. This sequence shows several things: The dilated, “always open” esophagus distal (below) the muscle; how to identify the cricopharyngeus muscle; and one way of injecting it.